A Potential Biomarker of Dental Pulp Regeneration: Wnt10a

نویسندگان

چکیده

In organs, multiple functionally differentiated cells and stem are organized to express specific functions through a series of complex interactions. The Wnt signaling pathway is deeply involved in these processes throughout life. dependence on spatiotemporal specificity the changes vivo interactions caused by balance distribution ligands antagonists. Regeneration thought involve reconstitution growth mechanism, thus control tissue regeneration has been attempted mimicking canonical signals. Wnt10a reported be tooth development regeneration. These findings indicate importance understanding reproducing involvement dental pulp for regenerative treatment. Accordingly, we examined signals morphologically examining over time regenerated using ectopic root implantation. Expression levels DKK1 suggest that expression does not increase continuously with as increases, which reflects Wnt. addition, Dkk1 kinetics had phase shift relative those Wnt10a: was low when high, decreased increased. results have an elaborate mechanism pulp, suggested previous reports. Moreover, percentage pulp. Therefore potential biomarker

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ژورنال

عنوان ژورنال: Journal of Hard Tissue Biology

سال: 2023

ISSN: ['1880-828X', '1341-7649']

DOI: https://doi.org/10.2485/jhtb.32.197